Post-Doctoral Position In The Group Of Pr Vivier

2 semanas atrás

Porto, Portugal Cnrs – Inserm – Aix Marseille University Tempo inteiro

Organisation/Company: CNRS – Inserm – Aix Marseille University
Department: Centre d'Immunologie de Marseille Luminy
Research Field: Biological sciences » Biology, Medical sciences » Cancer research
Researcher Profile: Recognised Researcher (R2)
Positions: PhD Positions
Country: France
Application Deadline: 31 Dec 2024 - 15:27 (Europe/Paris)
Type of Contract: To be defined
Job Status: Full-time
Hours Per Week: 40
Offer Starting Date: 2 Sep 2024
Is the job funded through the EU Research Framework Programme? Other EU programme
Is the Job related to staff position within a Research Infrastructure? No
Offer Description Postdoctoral scientist positions and engineers are available in 2024 (3 years and two years renewable contracts) at the Center of Immunology of Marseille Luminy and/or Institut Gustave Roussy in the team of Pr Eric Vivier .
The scientists will be part of a research program aiming at exploring new topics in Immuno-Oncology in collaboration with the Institut Gustave Roussy.
Context: New therapies that promote anti-tumor immunity have been developed over the last decade. Most of these immunomodulatory approaches have focused on enhancing T-cell responses, either by targeting inhibitory pathways with immune checkpoint inhibitors, or by targeting activating pathways, as with chimeric antigen receptor T cells or bispecific antibodies. Although these therapies have led to unprecedented successes, only a minority of patients with cancer benefit from these treatments, highlighting the need to identify new cells and molecules that could be exploited in the next generation of immunotherapy. Harnessing innate immunity is emerging as a promising therapeutic approach to improving the efficacy of cancer treatment and overcoming resistance to current immunotherapies targeting T cells. In particular, harnessing NK cells in cancer patients presents the dual advantage of inducing the killing of tumor cells, but also of participating in a multicellular immune response against tumor cells. Correlations have been observed between patient clinical outcome and NK cell infiltration at the tumor bed or cytotoxicity of peripheral NK cells, in several cancer indications.
We propose here to study the role of NK cells and innate lymphoid cells type 1 (ILC1) in certain cancer indications in order to propose innovative treatments for these diseases based on their manipulation by antibody-based drugs. In addition, we are also working on the sensitization of tumor cells to NK cell-mediated killing.
Our OFFER: We are looking for outstanding and highly motivated post-doctoral fellows with a PhD in Immunology or Onco-immunology and highly qualified engineers. Experience in cell culture, in vitro cytotoxicity assay, transcriptomics (scRNAseq, spatial), molecular biology and flow cytometry will be highly appreciated. Scientists will be part of a rich environment with full access to state-of-the-art technologies, which should ensure the successful development of the research programs.
The deadline for applications is end of August 2024.

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