Principal Investigator

3 semanas atrás

Lisboa, Portugal Fundação Champalimaud Tempo inteiro

**Principal Investigator - Computational Cancer Genomics****:
**Localização**: Botton-Champalimaud Pancreatic Cancer Center**Entidade Empregadora**: Fundação Champalimaud**Regime**: Tempo Inteiro**Posição**: Líderes de Grupo**Início da Candidatura**: 13 Maio. 2024**Fecho de Candidatura**: 31 Maio. 2024- Lead a dynamic research team focused on computational cancer genomics, providing scientific direction and mentoring junior staff;
- Design and execute experiments utilising whole genome sequencing technologies to study cancer biology, including tumour evolution, clonal dynamics, and genomic alterations;
- Develop and optimise bioinformatics pipelines for the analysis of WGS data, ensuring robust and reproducible results;
- Implement best practices for data quality control, variant calling, and annotation to identify driver mutations, structural variants, and other genomic aberrations associated with cancer;
- Collaborate with clinical partners to integrate genomic findings into precision medicine approaches for cancer diagnosis, prognosis, and treatment;
- Stay abreast of advancements in third generation sequencing platforms and emerging technologies, evaluating their potential impact on cancer genomics research;
- Publish research findings in high-impact peer-reviewed journals and present results at scientific conferences;
Contribute to grant writing and fundraising efforts to support ongoing research projects and secure additional funding for future initiatives.
- Requirements
- Research Field: Biological sciences; Biology; Computer science; Informatics
- Education Level: PhD or equivalent
- Years of Research Experience: More than 10
- English level: Excellent

Skills/Qualifications

Ph.D. or equivalent degree in genetics, genomics, bioinformatics, or a related field.

Specific Requirements
- Proven track record of research excellence in computational cancer genomics (at least 7 co-authored high impact factor publications), with a focus on whole genome sequencing analysis;
- Expertise in bioinformatics analysis of cancer WGS data, including proficiency with programming languages (e.g. Python and R) and best practice bioinformatic pipelines including GATK, SAMtools, BWA, Manta, GRIDSS, IGV;
- Experience (hands-on) with third-generation sequencing platforms (e.g., PacBio, Oxford Nanopore) and familiarity with long-read sequencing data analysis techniques;
- Experience working with High-Performance Computing cluster environments (e.g. SLURM);
- Expertise in bioinformatics analysis of RNAseq and single cell RNAseq data;
- Experience in controlled-access data management;
- Experience in developing and managing multicentre cancer genomics studies;
- Strong communication and leadership skills, with the ability to work effectively in a collaborative research environment;
- Demonstrated ability to secure research funding through grants or other mechanisms;
- Prior experience managing research projects and supervising research staff and students is preferred

Key Skills
- Leadership;
- Problem solving;
- Flexibility;
- Attention to Detail;
- Communication;
- Organisation;
- Initiative.

**Benefits**:

- Competitive fellowship commensurate with skills, qualifications and experience.
- Full immersion into a research excellence ecosystem with highly motivated researchers, supported by state-of-the-art technology and continuous development opportunities.

Maximum allowable duration of the contract including the respective renewals.

Eligibility criteria

Selection process

Evaluation Committee members

Markus Büchler (Director)

John P. Neoptolemos (Director of Clinical Research)

Peter Bailey (Director of Translational Research)

Craig Nourse (Manager of Advanced Platforms)

Application materials
- A letter of motivation (max. 2 pages), highlighting your suitability for the role, salary expectations and notice period.
- CV (max. 2 pages)
- Names and contact information for at least 2 references. If you do not wish that we contact current or past employers, please state so and why in your letter of motivation.

How to apply
- The call reference will be asked and not having may invalidate your submission;
- This call reference is **PI-CCG_BCPCC.**

Applications are also accepted in paper, sent or handed to:
Sueli Marques Spencer, Project Manager
Botton-Champalimaud Pancreatic Cancer Center
Avenida Brasília, 1400-038 Lisbon, Portugal

Notification of results

About Us

Research is at the heart of the Champalimaud Centre for the Unknown, a modern research and clinical facility situated on the waterfront in Lisbon, Portugal. The goal of Champalimaud Research (CR) is to perform world-leading fundamental and translational research. Current research work is focused on the fields of neuroscience, physiology and cancer. Champalimaud Research comprises a team of over 400 scientists from around the world. English is the official language of the Centre. Lisbon’s sunny Atlantic Mediterranean climate, vibrant culture and

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