Research Technician

**Research Technician at the van Gisbergen / Tissue Immunity Lab****:
**Localização**: Centro Champalimaud**Entidade Empregadora**: Fundação Champalimaud**Regime**: Tempo Inteiro**Posição**: Técnico**Início da Candidatura**: 04 Abr. 2024Champalimaud Foundation (Fundação D. Anna de Sommer Champalimaud e Dr. Carlos Montez Champalimaud), a private, non-profit research institution in Lisbon, Portugal, is looking for a Research Technician to join our team at the Champalimaud Research Programme.

The Research Technician will work on a project in the research group of Dr Klaas van Gisbergen in the Tissue Immunity Lab at the Champalimaud Foundation. He/she will be part of a larger research team in a collaborative initiative between the labs of Dr Joke den Haan at Amsterdam UMC, Dr Sonja Buschow at Rotterdam UMC and Dr van Gisbergen at the Champalimaud Foundation. The Research Technician will be working in close collaboration with co-workers in the lab and at the other institutes. His/her tasks will include lab management and the planning and execution of experiments.

The project

The aim of the project is to understand how T cells can be optimally geared to fight solid tumors using vaccination strategies. More specifically, we will explore how vaccination approaches can induce resident memory T cells to improve immune defense against cancer. We will focus on how the development of resident memory T cells can be instructed in the liver to provide local protection against hepatocellular carcinoma. The research will be performed using advanced techniques in flow cytometry and transcriptional profiling and using unique tools developed in house to visualize and manipulate resident memory T cells.

The lab

The lab of Tissue Immunity focuses on the development of memory T cells in infection and tumor settings and the transcriptional and molecular pathways underlying T cell differentiation. The eventual goal is to improve the exploit of T cells for the purpose of cancer immunotherapy. The lab is embedded in the department of Cancer and Physiology at the Champalimaud Foundation that provides a lively, internationally oriented, scientific environment with excellent facilities. The research is strongly multidisciplinary and includes neuroscience, tumor biology and tumor immunology making use of state-of-the-art techniques in in vivo models, molecular biology, flow cytometry and fluorescence microscopy.
- Department:_ Cancer and Physiology, Tissue Immunity (van Gisbergen) Lab

**Profile**:
Number and type of fellowships or contracts to be awarded

1 fellowship/s

Application start date

April 4th 2024

Application closing date

Open until filled.

Required Education Level

BSc/MSc in Biomedical Sciences or related areas.

**Requirements**:
Research Field: Biological sciences » Other
Education Level: Bachelor/Master Degree or equivalent

Specific Requirements
- Molecular techniques, transcriptional profiling and bioinformatics analysis.
- Excellent level of English.

**Benefits**:

- Competitive remuneration package commensurate with skills, qualifications and experience.
- Full immersion into a research excellence ecosystem with highly motivated researchers, supported by state-of-the-art technology and continuous development opportunities.

Maximum allowable duration of the contract including the respective renewals OR Initial duration

24 months with possibility of renewal.

Eligibility criteria

Selection process

Evaluation Committee members

Ines Ramos, Sara Correia, Daniela Silva and Klaas Van Gisbergen.

Application materials

CV and letter of motivation indicating 2 references (one single pdf document).

Proof of qualifications (certificates) may be required at a later date for the formalisation of the contract agreement. Degrees obtained abroad may need to be formally recognised in Portugal.

How to apply

The call reference will be asked and not having may invalidate your submission. This call reference is**:"RT KWF Van Gisbergen Apr2024"**

Applications are also accepted in paper, sent or handed to the Fellows Support Office at the Champalimaud Centre for the Unknown, Avenida Brasília, 1400-038 Lisbon, Portugal.

Notification of results

About Us

Research is at the heart of the Champalimaud Centre for the Unknown, a modern research and clinical facility situated on the waterfront in Lisbon, Portugal. The goal of Champalimaud Research (CR) is to perform world-leading fundamental and translational research. Current research work is focused on the fields of neuroscience, physiology and cancer. Champalimaud Research comprises a team of over 400 scientists from around the world. English is the official language of the Centre. Lisbon’s sunny Atlantic Mediterranean climate, vibrant culture and high quality of life make this a great place to live and work.

Relevant Institutional Information

HR Excellence in Research

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