Biological Evaluation of Radiotracers for PET Imaging of Mutated Isocitrate Dehydrogenases: A Cancer Research Opportunity
Há 4 dias
About the Project
The Imagerie Moléculaire et Stratégies Théranostiques UMR 1240, INSERM, UCA is seeking a researcher to work on a project focused on evaluating radiotracers for PET imaging of mutated isocitrate dehydrogenases in cancer. This project has the potential to revolutionize the diagnosis and treatment of various cancers, including glioma, acute myeloid leukemia, intrahepatic cholangiocarcinoma, and chondrosarcoma.
Background
Isocitrate dehydrogenases (IDH) are enzymes that play a crucial role in cellular metabolism, defense against oxidative stress, respiration, and oxygen-sensing signal transduction. However, mutations in these enzymes have been linked to several types of cancer. The project aims to develop non-invasive imaging techniques using positron emission tomography (PET) or single-photon emission computed tomography (SPECT) to detect the mIDH1 protein and determine the mutational status of patients' tumors.
Requirements
- Ph.D. degree or equivalent in biology or biomedical sciences
- Strong background in cancer biology, molecular biology, or biochemistry
- Experience in common biological assays, including cell culturing, Western Blotting, immunohistochemistry, and statistical analyses
- Knowledge of handling radioactive material
- Experience with in vitro characterisation of radiotracers (uptake, competition assay)
- Experience with tumor imaging or preclinical disease models for molecular imaging procedures
- Authorization to conduct experiments on animals - Level 1 or 2
- Excellent communication and writing skills in English
What We Offer
This is an exciting opportunity to work with a multidisciplinary team at the forefront of cancer research. The successful candidate will receive a competitive salary of approximately €45,000-€60,000 per annum, depending on experience. Additionally, we offer a dynamic and supportive working environment, opportunities for professional development, and a comprehensive benefits package.
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