Postdoctoral Researcher in Innate Immunity

Há 2 dias


Porto, Porto, Portugal Ens - Cnrs - Inserm Tempo inteiro

Job Description:

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We are seeking a highly motivated Postdoctoral Researcher to join our team at the Institut de Biologie de l'Ecole Normale Superieure, a leading research institution in France. Our laboratory is part of the European MaxImmun consortium, which aims to develop innovative therapeutic strategies to combat antimicrobial resistance.

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About the Job:

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The successful candidate will contribute to the understanding of genetic and epigenetic regulatory mechanisms of innate immune genes encoding antimicrobial peptides in human intestinal epithelial cells. They will also participate in the development of an immunostimulation strategy to fight against antimicrobial resistance through boosting the expression of antimicrobial peptides.

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Responsibilities:

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  • Conduct research on the fundamental regulatory mechanisms of human genes encoding antimicrobial peptides">
  • Characterize the action mechanisms of immunomodulatory molecules identified by screening capable of boosting expression of these genes from the mucosal innate immunity">
  • Study the activation and repression circuits of antimicrobial peptide gene regulation using genome and epigenome editing approaches, gene silencing by siRNAs, or pharmacological inhibitors">
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Requirements:

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  • PhD degree in a relevant field (Biology, Immunology, etc.)">
  • Expertise in genome and epigenome editing approaches, gene silencing by siRNAs, RNA-seq and data analysis, quantitative real-time PCR, ELISA assays, and human cell culture">
  • Excellent French and English language skills (written and spoken)">
  • A sense of organization, practical and critical mind, and ability to anticipate">
  • Mastery of Excel, Word, PowerPoint, Prism softs">
  • Curiosity, open-mindedness, ease-going attitude, prioritization skills, synthetic thinking, responsiveness, dynamism, rigor, and organization">
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What We Offer:

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Our team provides a stimulating work environment with opportunities for professional growth and collaboration with international partners. The contract period is 36 months, and the remuneration package includes a salary range of €30,000 - €33,000 per year, depending on experience.

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About Us:

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The European MaxImmun project is a consortium of six French, German, Swedish partners, and the ImmunRise Technologies biotechnology company, aiming to develop an innovative therapeutic strategy to combat antimicrobial resistance.

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Eligibility Criteria:

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  • Background in Immunology, Innate Immunity, Inflammation, Antimicrobial Peptides, and Host-Pathogen Interactions">
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Selection Process:

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Selection will be based on the application file and interview.



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