Postdoctoral Fellowship | Project Drug2Target, Compete2030-Feder-00672800

Position OverviewUniversity of Aveiro – Department CICECO (Aveiro Institute of Materials Research).
Postdoctoral Researcher (R2) – Biochemistry.
Start date: 1 September **.
Weekly hours: 35.Responsibilities- Develop and implement research activities within the "Drug2Target" project, focusing on the design, synthesis, and pre‐clinical evaluation of new platinum, palladium, and nickel‐based anticancer metallodrugs.
- Prepare and process biological samples (tissues, 2D/3D cell cultures, biofluids) for metabolomics analysis by Nuclear Magnetic Resonance (NMR) spectroscopy.
- Acquire, process, and conduct quality control of spectroscopic data;
perform advanced multivariate statistical analysis and biological interpretation using MATLAB, SIMCA, R, Chenomx, and MetaboAnalyst.
- Participate in in vitro and in vivo studies to assess therapeutic efficacy, toxicity, and mechanisms of action of new metal compounds.
- Integrate metabolic data with other cellular and molecular biology methodologies to identify biomarkers, altered pathways, and potential therapeutic targets.
- Prepare technical reports, manuscripts for publication in international scientific journals, and presentations for project meetings and scientific conferences.
- Collaborate with multidisciplinary teams, demonstrating autonomy in experimental protocols and critical thinking in data analysis.Qualifications- Doctoral degree in Biochemistry (or closely related field) obtained within three years prior to application.
- Independent experience in NMR spectroscopy, including operation and maintenance of NMR equipment for metabolomic analysis.
- Proficiency in multivariate statistical analysis and usage of MATLAB, SIMCA, R, Chenomx, and MetaboAnalyst.
- Background in cell culture (2D and 3D) and animal experimentation;
FELASA training and experience preferred.
- Prior work with platinum and palladium metallodrugs and cancer research, supported by publications.
- Ability to write and present scientific findings effectively.Benefits- Monthly maintenance allowance of €1,**.- Reimbursement for voluntary social security contributions when applicable.
- Access to state‐of‐the‐art NMR facilities and multidisciplinary research environment.Location & SupervisionWorkplace: Instituto de Biomedicina da Universidade de Aveiro (IBIMED).
Scientific supervision provided by Professor Dr. Luisa Alejandra Helguero.
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