Precision Medicine Strategies For Patients With Metastases Of Colorectal Carcinoma Resistant To[...]

Há 4 dias


Porto, Portugal Crcm Tempo inteiro

Organisation/Company: CRCM
Research Field: Medical sciences » Cancer research
Researcher Profile: Recognised Researcher (R2)
Country: France
Application Deadline: 1 May 2025 - 01:01 (Europe/Paris)
Type of Contract: Not Applicable
Job Status: Full-time
Offer Starting Date: 17 Apr 2024
Is the job funded through the EU Research Framework Programme? Not funded by a EU programme
Is the Job related to staff position within a Research Infrastructure? No
Offer Description Despite considerable progress in the therapeutic treatment of cancer patients, the vast majority of them face a relapse of their disease due to the development of drug resistance mechanisms.

We need to explore new approaches to counteract the emergence of such resistance and enable broad-spectrum treatments to maintain their efficacy without additional cytotoxicity. In particular, we want to investigate the importance of transient reprogramming in response to stress (treatment is considered a stress to the tumor) and how this might impact tumor spread. To this end, we will use relevant preclinical models that also take into account the role of the tumor microenvironment.
We are looking for a talented and experienced PhD researcher to work on resistance to novel treatments for aggressive/metastatic cancers (colon or PDAC).

Ideally, our mid-term goal is to propose the candidate for the national INSERM/CNRS competition within 3 years and make him/her a permanent researcher of the team to lead ambitious projects on the proposed topic (optional).

In the meantime, we will jointly apply for a European grant (DL: MSCA Sept 2023, ARC Post-doc in France, Fondation de France fellowships).
Environment Co-team leaders: E Mamessier (scientist, immunologist and expert in conducting translational studies at INSERM) and F Bertucci (oncologist, Institut Paoli Calmettes, Marseille, France). This joint leadership allows us to combine technical development and the exploration of new scientific topics with relevant clinical questions and access to patient samples. This has proven successful in the past and we would like to maintain this by forming a team of clinicians and scientists to lead a project.
The team consists of about 17 people: 5 clinicians (surgeon, oncologist, pathologist, all part-time), 3 computer analysts, 2 molecular technicians, 3 cell technicians, 2 lab assistants, 2 PhD students. A full-time scientist/biologist to work with the clinicians in the team on ambitious translational projects is currently sorely lacking and we are looking to strengthen our team.
The team is fully equipped for next generation sequencing (Nextseq500), pan-transcriptomic analysis (Affy), comparative genomic hybridization (Agilent), isolation and analysis of circulating tumor DNA (BioRad), isolation and analysis of circulating tumor cells (Parsortix) and microfluidic devices (Ibidi, Fluigent, ..).

We have established in silico gene expression databases with annotated clinical data, which are among the largest databases available today. We have also created our own bulk and single cell datasets and associated analysis pipeline.
We conduct prospective clinical trials that provide us with fresh blood and tumor samples to derive preclinical models (organoids from patient tumors, patient-derived xenografts).

If necessary, we also develop our own therapies (ADC or ASO).

We combine all these tools/technologies to develop precision medicine strategies in metastatic colorectal or breast cancer. Our goal is to improve overall survival in metastatic cancer through better classification of tumors, more therapeutic options, better targeting and a better understanding of resistance mechanisms to treatments.
Where to apply E-mail: ******
Requirements Research Field: Medical sciences » Cancer research
Education Level: PhD or equivalent
Education Level: Master Degree or equivalent
Skills/Qualifications:
PhD + one successful postdoc experience (paper IF > 12 in first position)
Willingness to focus on treatment resistance in the context of precision medicine, to explore the mechanisms of resistance to treatments in depth to gain a better understanding and provide new targeting opportunities for metastatic patients (CRC and PDAC)
Experience with manipulation of human samples (other than cell lines)
Extensive multidisciplinary experience (bioinformatics analysis, cell biology, biochemistry, etc.)

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