Call for Applications for a Phd Scholarship In

2 semanas atrás


Lisboa, Portugal Hovione Tempo inteiro

Join a Market Leader:
Hovione FarmaCiencia SA (Hovione) is a Portuguese company specialized in Health sciences, dedicated to the research, development and production of Active Pharmaceutical Substances (APIs), and drug products for pulmonary inhalation and oral delivery. Hovione innovates and leads worldwide in the field of pharmaceutical chemistry, as demonstrated by about 400 worldwide patents. The products and procedures developed at Hovione meet the high standards of compliance established by the International Conference Harmonization (ICH), Food and Drug Administration (FDA) and Health Authorities of European countries and Japan.

As an integral part of Hovione's Innovation Strategy, the PhD program** **Lung microphysiological system for predicting the bioavailability of dry powder inhalation (DPI) products** was created and awarded a PhD in Business (BDE) scholarship.

**SCHOLARSHIP**

The present call is open to a PhD in Business (BDE) Scholarship under the conditions and characteristics set forth in Article 6 of the FCT Research Grant Regulation in force in 2023.

**SCIENTIFIC AREA**: Biological engineering, biotechnology, biochemistry, cell biology or equivalent with demonstrated research experience.

You will be responsible to:
**WORK PLAN**

Developing the new generation of dry powder inhalation (DPI) drug products is increasingly more reliant on the mechanistic understanding of formulation effects, interactions, and distribution in lung tissues, especially in the complex air-liquid interfaces of pulmonary epithelia that regulate API solubility, clearance, and permeability, and that can drive the onset of potential adverse side effects. Testing these phenomena is becoming critical during drug product development, and to ensure their bioequivalence. Hovione R&D homes a unique combination of expertise in lung advanced in vitro lung air-liquid interface models (i.e. microphysiological systems, organs-on-chip, organoids, etc.) and in physiologically-relevant deposition and characterization of inhalable dose. We propose to leverage this unique knowledge hub to achieve the proposed research goals and impact. The overall Ph.D. thesis goal is to develop reproducible methodology to mechanistically predict lung permeability, clearance, metabolism, accumulation, and therefore local bioavailability of API from DPI formulations with a lung microphysiological system.

**WORKPLACE**

The implementation of the program will take place at Hovione's premises, in close collaboration with Instituto Superior Técnico.

**SUPERVISION**

The scientific supervisors of the program will be Prof. Tiago Fernandes (Institute Supervisor) and Alexandre Ribeiro (Hovione Supervisor).

**DURATION**

The scholarship has a maximum duration of 4 years; it is granted on a full-time basis and is awarded annually, for periods of 12 consecutive months and automatically renewable, unless under the applicable legislation the scholar fails to fulfill his / her assigned duties. The scholarship is scheduled to start in **September 2023** on an exclusive basis.

**RECIPIENTS**

This call is addressed to anyone who is eligible to participate in the Program.

**DEADLINE FOR SUBMISSION OF APPLICATIONS**

The call is open between 27/June/2023 and 14/July/2023.

**APPLICATIONS**

**EVALUATION**

The selection methods are as follows:

- Preliminary evaluation of CVs by Human Resources and supervisor
- Level of English;
- Motivation Letter
- Interview

Each item will be scored on a scale of 0-20, with the following weights: Curriculum vitae and experience (40%), English (10%), motivation letter (10%) and interview (40%).

**EVALUATION PANEL**

The evaluation panel comprises the Hovione's Scientific Advisors panel, Project Manager Innovation and Hovione Human Resources.

**PUBLICATION OF RESULTS**

The results of the evaluation, presented in descending order, are published through the Hovione website and sent to the applicants within the deadline set in Article 12 of the FCT Research Grants Regulation.

**FINANCING



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