Post-Doctoral Fellow in Pancreatic Cancer Research – Cancer Genome and Evolution Laboratory
4 semanas atrás
We are seeking a highly motivated and skilled Post-Doctoral Fellow to join our dynamic research team at the Botton-Champalimaud Pancreatic Cancer Centre.
This prestigious center is dedicated to advancing pancreatic cancer research and treatment through innovative approaches and multidisciplinary collaboration. The successful candidate will contribute to cutting-edge research aimed at understanding the molecular mechanisms of pancreatic cancer progression and developing novel therapeutic strategies.
Working within this state-of-the-art facility, you will have access to advanced technologies and a network of world-renowned experts in the field of pancreatic cancer.
The successful candidate will work within the Cancer Genome and Evolution laboratory led by Professor Vincenzo Corbo.
Duties and Responsibilities
1. Design and conduct experiments to investigate pancreatic cancer biology, including tumor heterogeneity, cell signaling pathways, tumor microenvironment, and drug resistance mechanisms;
2. Develop and optimize in vitro and in vivo models of pancreatic cancer;
3. Generate and maintain patient-derived organoids for pancreatic cancer research;
4. Utilize patient-derived organoids to study drug responses, tumor heterogeneity, and personalized treatment approaches;
5. Analyze and interpret complex experimental data using advanced statistical and bioinformatics tools;
6. Present research findings at team meetings, conferences, and scientific symposia;
7. Prepare manuscripts for publication in peer-reviewed journals;
8. Collaborate with other researchers and clinicians within the Botton-Champalimaud Pancreatic Cancer Centre and external partners;
9. Mentor and supervise junior researchers and graduate students;
10. Contribute to grant writing and funding applications;
11. Participate in translational research initiatives to bridge laboratory findings with clinical applications;
12. Engage in knowledge exchange and public outreach activities to promote pancreatic cancer awareness and research;
13. Prepare Standard Operating Procedures (SOPs) for laboratory techniques and experimental protocols;
14. Contribute to the development and maintenance of quality management systems within the research facility.
- Research Field: Biological sciences;
- Education Level: PhD or equivalent;
- Excellent level of English;
- 1 to 4 years of experience.
Skills/Qualifications
Key Skills
- Problem solving
- Flexibility
- Attention to detail
- Organisation
- Initiative
Specific Requirements
1. Ph.D. in Cancer Biology, Molecular Biology, Biochemistry, or a related field;
2. Strong background in cancer research, preferably with experience in pancreatic cancer, pancreatic neuroendocrine cancer, and RNA biology;
3. Expertise in molecular biology techniques, cell culture, and animal models;
4. Proficiency in data analysis, bioinformatics, and statistical methods using R or Python or equivalent language;
5. Excellent written and verbal communication skills;
6. Demonstrated ability to work independently and collaboratively in a multidisciplinary environment;
7. Track record of scientific publications in peer-reviewed journals.
Preferred Skills
1. Experience with advanced imaging techniques (e.g., confocal microscopy, live cell imaging).
2. Familiarity with next-generation sequencing and multi-omics data analysis.
3. Experience in data analysis using R and/or Python.
4. Knowledge of drug discovery and development processes.
5. Experience with grant writing and securing research funding.
- Competitive salary and benefits package;
- Opportunity for professional development and growth within a cutting-edge research environment;
- Contribute to impactful research that makes a difference in the field of pathology.
1. CV (max. 2 pages);
2. Letter of motivation (max. 2 pages), highlighting your suitability for the role, salary expectations, and notice period;
3. Names and contact information for at least 2 references. If you do not wish that we contact current or past employers, please state so and why in your letter of motivation.
Evaluation and Selection Criteria
All CVs and motivation letters will be reviewed by the selection committee. Reference letters will be requested from shortlisted candidates, and those candidates deemed particularly well suited for the position will be invited for an interview.
More about us
The Botton-Champalimaud Pancreatic Cancer Centre is a state-of-the-art facility comprising research laboratories, a day hospital, a surgical centre, as well as inpatient and intensive care facilities. The mission of the Botton-Champalimaud Pancreatic Cancer Centre is to develop new and effective treatments for pancreatic cancer. To accomplish this goal a multidisciplinary team of surgeons, clinicians, clinical trials specialists, cancer scientists, genomics experts, and computational biologists work together to deliver world-leading outcomes for patients with pancreatic cancer.
Additional Institutional Information
In line with our community guidelines and Equality, Diversity and Inclusion policy and Gender Equality Plan, no candidate may be privileged, favoured, prejudiced or deprived of any right or excluded from any duty on the basis of age, sex, gender identity, sexual orientation, race/ethnicity, disability, chronic illness, language, nationality, territory of origin, family status (marital, pregnancy and maternity, having or not having dependents), socioeconomic situation, education, religion, political or ideological beliefs, trade union membership, or on any other grounds which are irrelevant to decision-making.
Consistent with our personnel policies, your first six (6) months will be probationary. This probationary period is an important time for you to understand your position and see if you and the Department are satisfied with expectations. At approximately the six (6) month mark, you will meet with your supervisor to review your performance and evaluate the job match.
Legal Notices
The present call has the sole purpose of filling the indicated research position. This call may be cancelled at any time on or before the jury's evaluation of all eligible candidates and the recruitment process shall be concluded on the day of the full execution of the contract between the Champalimaud Foundation and the selected candidate.
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