Structural Biologist for RNA Polymerase Research and Drug Development
Há 4 dias
Company Overview
Institut Pasteur is a leading institution in fundamental molecular biology and applied microbiology in Europe. It is an equal opportunity employer that fosters cross-disciplinary collaborations within the campus in a dynamic and enriching environment, in the center of Paris.
Salary
We offer a competitive salary estimated to be around €45,000 per annum, commensurate with experience, to support your career growth and provide a comfortable lifestyle in Paris.
Job Description
A post-doctoral fellowship for 2 years in structural studies of highly simplified versions of RNA polymerases from phages or parasites is available in the lab of Architecture and Dynamics of Biological Macromolecules at Institut Pasteur, Paris (http://dynstr.pasteur.fr). The core expertise of the lab is in the field of structural biology, especially of DNA and RNA polymerases, providing crucial information that is used as input for protein engineering and design. Another aspect is the design of drugs against viruses or parasites.
Required Skills and Qualifications
We seek a post-doctoral fellow with a strong profile to reinforce these areas. Candidates should have proven expertise in protein expression, purification, and cryo-EM single-particle analysis. We are looking for a structural molecular biologist or biochemist with experience in solving structures of biological macromolecules using cryo-EM techniques, and a PhD degree in one of the aforementioned fields.
Benefits
Access to excellent specialized platforms and facilities is granted in electron microscopy (1 Titan and 2 Glacios), protein expression and purification, NMR and mass spectrometry, as well as biophysics. Potential applications concern finding effective drugs against RNA polymerases of parasites, as well as the design of RNA polymerases with the ability to incorporate modified nucleotides or amplify RNA in PCR-like cycles.
Others
The work will involve close collaboration with the research team at Institut Pasteur, Paris, and may involve some travel to other institutions for training or collaborations. If you are a motivated and skilled researcher looking to advance your career in structural biology, we encourage you to apply for this exciting opportunity.
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