Structural Characterization Of Rna Lipid Nanoparticles For Therapeutic Applications
2 semanas atrás
Organisation/Company: Laboratoire de Bioimagerie et Pathologies UMR7021 - CNRS
Department: Faculty of Pharmacy
Research Field: Biological sciences » Biological engineering, Technology » Pharmaceutical technology
Researcher Profile: First Stage Researcher (R1)
Positions: PhD Positions
Country: France
Application Deadline: 15 Jan 2025 - 00:00 (Europe/Paris)
Type of Contract: Temporary
Job Status: Full-time
Hours Per Week: 35
Offer Starting Date: 1 Mar 2025
Is the job funded through the EU Research Framework Programme? Not funded by a EU programme
Is the Job related to staff position within a Research Infrastructure? No
Offer Description
There is a growing interest in the therapeutic use of nucleic acids. Nevertheless, one of the primary challenges to their clinical utilisation is their intracellular delivery, which necessitates assistance due to their negative charges, high molecular weight and low stability. Recently, lipid nanoparticles (LNPs) have been developed as a means of vectorising RNA (siRNA, mRNA) (Nobel Prize in Medicine 2023). The most common formulations comprise an ionisable lipid, a phospholipid, a cholesterol derivative and a PEGylated lipid.
Fluorescence spectroscopy and microscopy have previously been employed to examine the morphological and biological characteristics of LNPs. As part of this PhD, we intend to investigate the structural characteristics of LNPs through the utilisation of fluorescent probes with environmental sensitivity to local polarity, hydration, and viscosity.
This project is being conducted in collaboration with two laboratories at the University of Lyon to integrate the findings from diverse complementary approaches, including nuclear magnetic resonance (NMR) and electron microscopy.
Where to apply
E-mail: ******
Requirements
Research Field: Biological sciences » Biological engineering, Engineering » Biomedical engineering
Education Level: Master Degree or equivalent
Skills/Qualifications:
The candidate will ideally have a background in biophysics with notions of instrumental development.
The candidate should be motivated to learn and develop techniques in biophysics, biotechnology and bio-imaging in relation to fluorescence microscopy.
He/she should have good interpersonal skills, in particular the ability to work in a team at the interface between several research units.
Languages: ENGLISH (Level: Good)
Years of Research Experience: None
Additional Information
Work Location(s)
Number of offers available: 1
Company/Institute: Laboratoire de Bioimagerie et Pathologies UMR7021 - CNRS
Country: France
City: Illkirch
Postal Code: 67400
Street: 74 route du rhin E010
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